Acute Poisoning (Ex. Organophosphate)

Acute

What is Acute Poisoning (Ex. Organophosphate)?

Toxic exposure; organophosphates inhibit cholinesterase.

Symptoms

SLUDGE (salivation, lacrimation, urination, defecation), bradycardia, miosis.

Risk Factors

Occupational exposure, intentional ingestion.

Complications

Respiratory failure, intermediate syndrome.

Prevention

Safe storage, protective equipment.

Procedures

Decontamination, antidotes (atropine, pralidoxime), airway support, dialysis/hemoperfusion for certain toxins.

How is it diagnosed?

How is it diagnosed?

Management. Selective IgM patients are managed in the same fashion as other antibody deficiencies. IRT is given if there is a significant associated functional antibody deficiency. Prophylactic antibiotics and prompt treatment of febrile illness are crucial.

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How is it treated?

Treatment for acute myeloid leukemia is vital. It varies with the patient and stage of the disease. Treatment options include

For such patients, intravenous immunoglobulin (IVIG) replacement may be an option. Prophylactic and/or rigorous therapeutic antibiotic treatments may be beneficial. Fresh frozen plasma may be considered for severe infections.

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